Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

Almost all multiple myeloma (MM) cases have been demonstrated to be linked to earlier monoclonal gammopathy of undetermined significance (MGUS). Nevertheless, there are no identified characteristics in the diagnosis of MGUS that have been helpful in differentiating subjects whose cancer may progress to a malignant situation. Regarding malignancy, the role of lymphocyte subsets and cytokines at the beginning of neoplastic diseases is now incontestable. In this review, we have concentrated our attention on the equilibrium between the diverse lymphocyte subsets and the cytokine system and summarized the current state of knowledge, providing an overview of the condition of the entire system in MGUS and MM. In an age where the therapy of neoplastic monoclonal gammopathies largely relies on drugs capable of acting on the immune system (immunomodulants, immunological checkpoint inhibitors, CAR-T), detailed knowledge of the the differences existing in benign and neoplastic forms of gammopathy is the main foundation for the adequate and optimal use of new drugs

Оцінка дії бальзаму "Трускавецький" в складі стандартного бальнеотерапевтичного комплексу на нейро-гормональну регуляцію у дітей шкільного віку

Бальзам "Трускавецкий", включенный в состав стандартного бальнеотерапевтического комплекса (СБТК) курорта Трускавец, у детей без иммунодефицита реверсирует ваготонический эффект СБТК в симпатотонический и снижает уровень кортизола, не влияя существенно на повышенный уровень альдостерона. У детей с иммунодефицитом симпатотонический и кортизолингибиторный эффекты бальзама проявляются менее отчетливо.Balm "Truskavets'kyi", included in structure of standard balneotherapeutic complex (SB&C) of a spa Truskavets', at children without immunodeficiency reverces vagotonic effect of SBTC in sympathotonic also reduces a cortisol level, not influencing essentially on the increased aldosteron level. At children with immunodeficiency sympathotonic and cortisolinhibiting effects of balm are shown less clearly

The spinning jenny and the guillotine: technology diffusion at the time of revolutions

Why was England the cradle of the Industrial Revolution? The present work shows that scale economies and demand, combined with the conditions of the relative prices of input factors, allow to provide a purely economic answer to this question. The labor-saving innovations of the Industrial Revolution were profitable only if, after their adoption, sales expanded enough to cover the upfront cost of capital. For some time, England was the only country in which sales exceeded the minimum threshold required to make adoption profitable. This fact is illustrated here by means of a detailed case study centered on the cotton industry and on the adoption of the spinning jenny in England and in France at the dawn of the Industrial Revolution. By then, the sufficiently large and relatively well-off English middle class could guarantee to cotton spinners a level of sales that was not viable in France, where income was lower and more concentrated in the hands of the upper classes

Heterogeneous pair approximation for voter models on networks

For models whose evolution takes place on a network it is often necessary to augment the mean-field approach by considering explicitly the degree dependence of average quantities (heterogeneous mean-field). Here we introduce the degree dependence in the pair approximation (heterogeneous pair approximation) for analyzing voter models on uncorrelated networks. This approach gives an essentially exact description of the dynamics, correcting some inaccurate results of previous approaches. The heterogeneous pair approximation introduced here can be applied in full generality to many other processes on complex networks.Comment: 6 pages, 6 figures, published versio

A Three-dimensional Printed Low-cost Anterior Shoulder Dislocation Model for Ultrasound-guided Injection Training.

Anterior shoulder dislocations are the most common, large joint dislocations that present to the emergency department (ED). Numerous studies support the use of intraarticular local anesthetic injections for the safe, effective, and time-saving reduction of these dislocations. Simulation training is an alternative and effective method for training compared to bedside learning. There are no commercially available ultrasound-compatible shoulder dislocation models. We utilized a three-dimensional (3D) printer to print a model that allows the visualization of the ultrasound anatomy (sonoanatomy) of an anterior shoulder dislocation. We utilized an open-source file of a shoulder, available from embodi3D® (Bellevue, WA, US). After approximating the relative orientation of the humerus to the glenoid fossa in an anterior dislocation, the humerus and scapula model was printed with an Ultimaker-2 Extended+ 3D® (Ultimaker, Cambridge, MA, US) printer using polylactic acid filaments. A 3D model of the external shoulder anatomy of a live human model was then created using Structure Sensor®(Occipital, San Francisco, CA, US), a 3D scanner. We aligned the printed dislocation model of the humerus and scapula within the resultant external shoulder mold. A pourable ballistics gel solution was used to create the final shoulder phantom. The use of simulation in medicine is widespread and growing, given the restrictions on work hours and a renewed focus on patient safety. The adage of see one, do one, teach one is being replaced by deliberate practice. Simulation allows such training to occur in a safe teaching environment. The ballistic gel and polylactic acid structure effectively reproduced the sonoanatomy of an anterior shoulder dislocation. The 3D printed model was effective for practicing an in-plane ultrasound-guided intraarticular joint injection. 3D printing is effective in producing a low-cost, ultrasound-capable model simulating an anterior shoulder dislocation. Future research will determine whether provider confidence and the use of intraarticular anesthesia for the management of shoulder dislocations will improve after utilizing this model

Grid computing technologies for renewable electricity generator monitoring and control

In this paper we discuss the use of real-time Grid computing for the monitoring, control and simulation of renewable electricity generators and their associated electrical networks. We discuss briefly the architectural design of GRIDCC and how we have integrated a number of real (solar, CHP) and simulated conventional power generators into the GRIDCC environment. A local weather station has also been attached to an Instrument Manager to alert experts appropriately when the Solar Array is not generating. The customised remote control and monitoring environment (a virtual control room), distributed using a standard web server, is discussed

Viscoelastic Characterization and Degradation Stability Investigation of Poly(butylene-adipate-co-terephthalate) - Calcium-Phosphate Glass Composites

In this work new biodegradable composite materials based on poly(butylene-adipate-co-terephthalate) (PBAT) reinforced with water-soluble calcium-phosphate glass (CPG) microparticles at different filler concentration (0, 4, 10, 20 and 40 wt%) were characterized by dynamic-mechanical analysis (DMA), aging and fragmentation tests. DMA results showed increasing storage modulus (E') values with the filler content, without a significant modification of the glass transition temperature (Tg), translating in a reinforcing effect of the filler particles with good interphase adhesion. The creep compliance decreased with the increase of the CPG content, confirming a greater resistance of the composites to deformation under constant stress. The stability to weathering agents and the degree of fragmentation in laboratory-scale composting conditions were also tested, obtaining a higher sensitivity to degradation of the PBAT-based composites with the increase of CPG content. Overall, the addition of CPG particles in a PBAT matrix produced stiffer composites, with modulation of the properties based on the filler content, enhancing at the same time their degradation rate, making them a promising and more sustainable alternative to traditional polymers

The role of anger rumination and autism spectrum disorder– Linked perseveration in the experience of aggression in the general population

This study (a) examined the role of anger rumination as a mediator of the relation between social anxiety and the experience of anger, hostility, and aggression, in the general population, and (b) evaluated the degree to which the presence of autism spectrum disorder characteristics moderates the indirect influence of anger rumination. We then explored whether social cognition and perseveration characteristic of autism spectrum disorder uniquely accounted for the predicted moderation. In this survey study of young adults (n = 948), anger rumination mediated the relation between social anxiety and hostility, as well as verbal and physical aggression, as predicted. Greater autism spectrum disorder characteristics augmented the effect of social anxiety on hostility and physical aggression by increasing the effect of anger rumination, but not by increasing the effect of social anxiety on anger rumination. Implications for developing treatment approaches that target hostility and aggression among young adults who may not be formally diagnosed but have characteristics of autism spectrum disorder are discussed

Open and / or laparoscopic surgical treatment of liver hydatic cysts

Hydatid disease is a severe parasitic disease with a widely ranging distribution. In the human being the liver is the most frequent organ affected. 1 The treatment should be individualized to the morphology, size, number and location of the cysts, that is why a variety of surgical operations have been advocated from complete resection like total pericystectomy or partial hepatectomy to laparoscopy to a minimally invasive procedures like percutaneous aspiration of cysts to conservative drug therapy. 3-4 This study compares laparoscopic versus open management of the hydatid cyst of liver the surgical approach to liver echinococcosis is still a controversial issue and shows our results of surgical treatment of liver hydatid cysts during a 3-years period